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The serious and the common side effects of the ADVAIR (fluticasone and salmeterol) are the Oral thrush (oral candiadiasis), throat irritation, hoarseness or change in the voice, muscle and bone pain, severe or intermittent headache, respiratory infections including the viral origin, bronchospasm (tightness or difficult in breathing, arrthymia, tremors, tachycardia, nervousness